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Saturday, March 23, 2013
Thursday, March 21, 2013
Video: PFT: Ravens owner wants Reed?? |? So do Texans
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Source: http://nbcsports.msnbc.com/id/21134540/vp/51249361#51249361
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Inherited genetic variations have a major impact on childhood leukemia risk
Mar. 19, 2013 ? Humans have between 20,000 and 25,000 genes that carry instructions for assembling the proteins that do the work of cells. Work led by St. Jude Children's Research Hospital found that children who inherit certain variations in four particular genes are at much higher risk of developing acute lymphoblastic leukemia (ALL).
The study also showed that Hispanic patients were more likely than patients of European or African ancestry to inherit high-risk versions of two of these genes. ALL rates are known to be higher among Hispanic children than those of European or African ancestry, this discovery points to at least one reason for that difference.
Each person's genome includes two copies of each gene, one from each parent. Thus, individuals could inherit up to eight high-risk versions of the four genes tied to an increased ALL risk. In this study, researchers found that having more than five copies of the risk genes resulted in a nine-fold greater risk of developing ALL in childhood than inheriting no more than one copy.
The report appears online March 19 in the Journal of the National Cancer Institute.
The findings stem from one of the largest multi-ethnic studies of genetic variation and ALL susceptibility ever conducted. The work included 2,450 pediatric ALL patients and 10,977 individuals from diverse racial and ethnic backgrounds without the disease.
The study's senior author, Jun J. Yang, Ph.D., an assistant member of the St. Jude Department of Pharmaceutical Sciences, said that the absolute risk for a particular child of developing ALL remains low. "ALL is a complex disease that likely involves many genes," he said. "The discoveries we are reporting in this paper are an important step forward in terms of understanding why children develop ALL in the first place, particularly for those with African or Hispanic ethnicity. However, this is probably still just a small part of the complete picture."
Along with providing insight into ethnicity and ALL risk, the study also offered clues to understanding the age pattern of ALL, which peaks in children ages 2 to 4. These findings suggest that younger patients might be most vulnerable to the effects of the high-risk gene variations.
This year about 3,000 children in the U.S. will be diagnosed with ALL, making it the most common childhood cancer. It is also among the most curable. Evidence that inheritance plays a role in childhood ALL risk has been building in recent years, but previous studies focused almost exclusively on patients of European ancestry. Thanks in part to new statistical methods for studying genetic variation in more diverse populations, this study expanded the quest to understand the genetic basis of ALL risk to include patients of African and Hispanic as well as European ancestry.
The effort involved ALL patients treated at St. Jude and through the Children's Oncology Group, the world's largest cooperative pediatric cancer research organization, As a comparison, investigators also screened DNA from individuals without ALL. Researchers used an automated system to check each person's DNA for 709,059 gene variations. In this study, ethnicity was assigned based on gene variations representative of European, African and Native American ancestry.
Previous studies from St. Jude and others linked pediatric ALL risk to common differences in the ARID5B, IKZF1, CEBPE and CDKN2A/2B genes. All play a role in normal blood and immune system development. ALL is a cancer of certain immune cells. In this study, researchers also discovered several variations in the gene PIP4K2A, which were associated with an elevated pediatric ALL risk. Hispanic patients were more likely than others in this study to inherit high-risk versions of the ARID5B and PIP4K2A genes, while African-American patients were less likely to have these variants.
The study's first authors are Heng Xu and Wenjian Yang, both of St. Jude. The other authors are Virginia Perez-Andreu, Yiping Fan, Cheng Cheng, Deqing Pei, Charles Mullighan, Deepa Bhojwani, Ching-Hon Pui, William Evans and Mary Relling, all of St. Jude; Meenakshi Devidas, University of Florida, Gainesville; Paul Scheet, University of Texas MD Anderson Cancer Center, Houston; Esteban Gonzalez Burchard, Celeste Eng, Scott Huntsman, Dara Torgerson and Mignon Loh, all of the University of California, San Francisco; Michael Dean, National Cancer Institute; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; Paul Martin, Duke University, Durham, N.C.; Bruce Camitta, Medical College of Wisconsin; W. Paul Bowman, Cook Children's Medical Center, Ft. Worth; Cheryl Willman, University of New Mexico, Albuquerque; William Carroll, New York University; and Stephen Hunger, University of Colorado, Aurora.
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The above story is reprinted from materials provided by St. Jude Children's Research Hospital.
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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/jUB8fBTlyS0/130319201943.htm
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Tuesday, March 19, 2013
US: Congo warlord Ntaganda turns himself in
KIGALI, Rwanda (AP) ? A Congolese warlord accused of conscripting child soldiers who had lived as an international fugitive for years surrendered to the United States Embassy in Rwanda on Monday and asked to be transferred to the International Criminal Court, a U.S. State Department spokeswoman said.
The move marks a major advance in efforts to prosecute Bosco Ntaganda, who had become a symbol of impunity in Africa as he played tennis and lived in an upscale villa in eastern Congo despite the international warrants for his arrest.
State Department spokeswoman Victoria Nuland confirmed that Ntaganda walked into the U.S. Embassy in Kigali on Monday and asked to be transferred to the International Criminal Court at The Hague, Netherlands. She said the U.S. was consulting with the Rwandan government.
"We want to facilitate that request," she said. "We strongly support the work that the ICC is doing to investigate the atrocities committed in the Democratic Republic of the Congo. And we are going to continue to work with the ICC on this matter."
The ICC first indicted Ntaganda in 2006. However despite that warrant, he went on to become a general in the Congolese army, living freely in eastern Congo.
The ICC has no police force and has to rely on member states to detain those it indicts. Congo failed to apprehend him for years, and the United States is not a member.
"If he's actually handed over to the International Criminal Court or a court that would prosecute him, that would be a huge step forward in the fight for justice in eastern Congo," said Carina Tertsakian, a senior researcher for Human Rights Watch.
The allegations against Ntaganda date back to crimes allegedly committed a decade ago in northeastern Congo. However, human rights groups say he has been implicated in other attacks on civilians in eastern Congo during his time as a fugitive.
News of Ntaganda's surrender first came in a Tweet and later in an official communique from Rwandan Foreign Minister and government spokeswoman Louise Mushikiwabo.
While Ntaganda was long believed to have enjoyed Rwanda's support, his relationship with the country where he was born has been unclear ever since his rebel movement split into two different factions earlier this month.
It was unclear why Ntaganda choose to surrender, and to turn himself into the U.S. embassy, after years at large, though the split within his group may have left him more vulnerable. The move comes days after Ntaganda's ally Jean-Marie Runiga was detained by Rwandan authorities. The leader of a rival faction within the M23 movement at the time vowed to go after Ntaganda next.
The news of Ntaganda's surrender was hailed by Congolese government spokesman Lambert Mende.
"We are confident they will hand him over to justice," he said of the U.S. officials in Kigali.
Nicknamed "The Terminator," for his ruthless actions, Ntaganda was born in Rwanda in 1973, and moved to the neighboring nation of Congo as a teenager.
He was first indicted in 2006 by the International Criminal Court for conscripting and using child soldiers during his time as a senior commander in a Congolese rebel group accused of terrorizing the Ituri region of eastern Congo between 2002 and 2003.
He later joined and rose through the ranks of a different rebel group, the National Congress for the Defense of the People, which signed a peace accord with the Congolese government on March 23, 2009.
That accord paved the way for Ntaganda and his fellow rebels to join the ranks of the regular Congolese army.
Then last spring, he and his men began defecting from the Congolese army by the hundreds, claiming that the government had failed to uphold their end of the 2009 deal.
They started a new rebellion, dubbed the M23, in honor of the March 23 signing of the now-defunct 2009 accord. And in November last year, the rebel group marched into and seized control of the provincial capital of Goma.
Ntaganda's exact role in the M23 rebellion remained murky. Human rights groups accused him of leading it, while other M23 leaders attempted to distance themselves from the fugitive general.
Rights groups on Monday called for Ntaganda's swift prosecution.
"Bosco Ntaganda is not called 'The Terminator' for nothing. The U.S. should immediately hand him over to the International Criminal Court for trial," said Sasha Lezhnev, senior analyst for the Enough Project in Washington, who closely follows Congo. "This would send serious signals to current and future warlords who continue to perpetrate atrocities in eastern Congo."
In Congo, Henri Bora Ladyi, who works at the Conflict Resolution Center which helps demobilize child soldiers, including some who fought in Ntaganda's rebel army, said: "It's a relief, but justice must be done. We fear that he will be kept in Rwanda and won't be extradited. Now what is important is to create space so that children in the M23 can leave the movement."
___
Gouby contributed to this report from Goma, Congo. Associated Press writers Rukmini Callimachi and Krista Larson also contributed to this report from Dakar, Senegal.
Source: http://news.yahoo.com/us-congo-warlord-ntaganda-turns-himself-185432533.html
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Pinterest redesign shows pins related by creator and popularity, stokes curiosity
Going on a Pinterest spree isn't always easy -- not when there's been extra work involved in exploring someone else's board, or figuring out what else is similar. The company may have licked both of those problems with a redesign that's exiting its testing phase today. As of now, visiting a pin will show others from the same board or company, as well as items that fellow explorers have pinned alongside the one you're viewing. Lower-profile changes are in store as well: the pin content itself is bigger, and the site will finally remember your place when you step back from a curious click. Web-based Pinterest fans should soon get an invitation to use the discovery-friendly revamp, while the Android and iOS apps will eventually see the new tricks through updates.
Filed under: Internet
Via: The Next Web
Source: Pinterest
Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/BlDJLFb7U4Y/
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Monday, March 18, 2013
Can an Honest Conversation About Race Be Inoffensive? (Atlantic Politics Channel)
dyna markup: zodiac yeats: Home Improvement Tips for Spring - ECI ...
March 20 is the first day of spring! Is your home ready for April showers and May flowers? If not, we?ve put together some home maintenance tips to prepare your home for the bright sunshine to come.
- Check your gutters. The earlier spring months are know for bringing a lot of rain, so it?s important to check for loose or leaky gutters. If they are clogged or full of debris, the water can end up in the basement or crawl space of your home. Check to make sure your gutters lead away from your foundation and are free of any trash.
- Inspect your roof shingles. From the ground, visually check your roof shingles for any damage from the winter. Replace any shingles that are cracked, buckled or loose as the summer sun can do serious damage to roof shingles. Plumbing vents, chimneys and skylights should be checked and repaired by a qualified roofer.
- Store firewood away from the home. Keep your firewood 2 feet from your home and at least 18 inches off the ground. Firewood kept near the house can attract spiders, snakes, rats and other pesky insects you don?t want running around your home.
- Check your hose faucets. Over the winter, the faucet pipes can freeze due to the cold weather. You can check them yourself by turning the water on and placing your thumb over the opening. If you can stop the water from coming out, more than likely the pipe is damaged and will need to be replaced.
- Prepare your lawn equipment. Check your gas and battery powered lawn mower, weed trimmer, etc and make sure they are ready for the summer. Cleaning the equipment and installing new cutting blades will make the yardwork easier.
ECI Construction has over 25 years of home remodeling and home repair experience. As a North Carolina local, President Doug Muehle understands the effects the seasons can have on a home. If you?re ready to prepare your home for the upcoming warmer months, do not hesitate to give him and his team a call. Contact the best Raleigh home remodeling company by calling 919-971-6415 or filling out their online contact form.
Source: http://www.eciconstructionnc.com/blog/home-improvement-tips-for-spring
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Source: http://zodiac-yeats.blogspot.com/2013/03/home-improvement-tips-for-spring-eci.html
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